منابع مشابه
Safety of Fixed Dose of Antihypertensive Drug Combinations Compared to (Single Pill) Free-Combinations
To compare serious adverse events of fixed-dose dual antihypertensive drug combination (FIXED) to component-based free-combination (FREE).A population-based nationwide cohort from the French Health Insurance System included subjects over 50 years with first time claims (new user) in the second half of 2009 for a calcium-channel blocker or a thiazide-like diuretic in combination with either an a...
متن کاملFixed Combinations in Antihypertensive Therapy
Several studies have now confirmed that optimal targets of blood pressure (BP) could rarely be reached by monotherapy and various drug combinations are required to do this more effectively. However, the best way to increase patient compliance may be fixed combinations of two or more drugs in a single pill. With further research into mechanisms of action and development of new drugs, it became e...
متن کاملDifferences in glucose tolerance between fixed-dose antihypertensive drug combinations in people with metabolic syndrome.
OBJECTIVE We sought to test the hypothesis that a fixed-dose combination of trandolapril/verapamil-SR (T/V) is superior to a fixed-dose combination of losartan/hydrochlorothiazide (L/H) on glucose tolerance in hypertensive patients with impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS A prospective, randomized, open-label, blinded-end points design was used to assess the effects ...
متن کاملPolypharmacy versus Drug Combinations
Drug combinations have been known to be used either for increasing effcctivity or for decreasing side-efFects. It is only when multiple drugs are prescribed without adequate scientific evidence in their favour then such practices need careful scrutiny. Multiple drug use in psychiatry has recently gained currency and so require thoughtful consideration. The term polypharmacy is generally used to...
متن کاملDrug interactions of antihypertensive agents
Adverse drug-drug interactions may occur when a major therapeutic mechanism of one drug class (such as bradycardia with a beta blocker) is excessively exaggerated by the addition of another heart-rate slowing antihypertensive, such as verapamil. The most important interactions at the molecular level are those of the hepatic enzyme, cytochrome (CYP) 3A4. A classic example is the inhibitory effec...
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ژورنال
عنوان ژورنال: Journal of the Korean Medical Association
سال: 2014
ISSN: 1975-8456,2093-5951
DOI: 10.5124/jkma.2014.57.3.253